The administration to Indonesians of monosodium L-glutamate in Indonesian foods: an assessment of adverse reactions in a randomized double-blind, crossover, placebo-controlled study

J Nutr. 2000 Apr;130(4S Suppl):1074S-6S. doi: 10.1093/jn/130.4.1074S.


Monosodium L-glutamate (MSG) has been suggested to cause postprandial symptoms after the ingestion of Chinese or oriental meals. Therefore, we examined whether such symptoms could be elicited in Indonesians ingesting levels of MSG typically found in Indonesian cuisine. Healthy volunteers (n = 52) were treated with capsules of placebo or MSG (1.5 and 3.0 g/person) as part of a standardized Indonesian breakfast. The study used a rigorous, randomized, double-blind, crossover design. The occurrence of symptoms after MSG ingestion did not differ from that after consumption of the placebo.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cooking*
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Food Additives / administration & dosage
  • Food Additives / adverse effects*
  • Humans
  • Indonesia
  • Male
  • Middle Aged
  • Nausea / chemically induced
  • Placebos / adverse effects
  • Sodium Glutamate / administration & dosage
  • Sodium Glutamate / adverse effects*


  • Food Additives
  • Placebos
  • Sodium Glutamate