Chronic invasive fungal rhinosinusitis

Otolaryngol Clin North Am. 2000 Apr;33(2):375-87. doi: 10.1016/s0030-6665(00)80012-2.


Chronic invasive fungal rhinosinusitis is an increasingly recognized, but inadequately characterized, disease entity which is separate and distinct from acute fulminant invasive fungal sinusitis and allergic fungal sinusitis. Chronic invasive fungal rhinosinusitis is divided into granulomatous and nongranulomatous subtypes based on histopathology, but the clinical distinction between the two subtypes is not clear. Current management includes varying degrees of surgical débridement and a prolonged course of antifungal agents. A protracted clinical course with recurrence after treatment is common.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Aspergillosis*
  • Aspergillus fumigatus / isolation & purification*
  • Chronic Disease
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Middle Aged
  • Rhinitis / diagnosis
  • Rhinitis / drug therapy
  • Rhinitis / microbiology*
  • Sinusitis / diagnosis
  • Sinusitis / drug therapy
  • Sinusitis / microbiology*
  • Tomography, X-Ray Computed


  • Antifungal Agents
  • Amphotericin B