Suppression of heat-induced HSP-70 by simultaneous exposure to 50 mT magnetic field

Life Sci. 2000 Feb 18;66(13):1187-96. doi: 10.1016/s0024-3205(00)00424-0.

Abstract

Effect of extremely low frequency magnetic field (ELFMF) at 50 mT and 60 Hz on heat-induced expression of heat shock protein 70 (hsp-70) was examined in HL60RG cells. No increase in hsp-70 production was observed in the cells after exposure to 50 mT ELFMF alone. Simultaneous exposure to 50 mT ELFMF in combination with mild heat at 42 and 40 degrees C suppressed heat-induced hsp-70 expression. The suppression of hsp-70 occurred when cells were simultaneously exposed to both for longer periods of more than 5 h. However, the suppression of hsp-70 was not observed at a magnetic density of 5 and 0.5 mT. This result suggests that exposure to 50 mT ELFMF may act on a protection against the concomitant mild heat stress in HL60RG cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • Cell Line
  • HSP70 Heat-Shock Proteins / biosynthesis*
  • Hot Temperature*
  • Humans
  • Magnetics*
  • Tumor Cells, Cultured

Substances

  • HSP70 Heat-Shock Proteins