Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens

J Med Chem. 2000 Mar 23;43(6):1045-9. doi: 10.1021/jm990618n.

Authors

Y S Or¹, R F Clark, S Wang, D T Chu, A M Nilius, R K Flamm, M Mitten, P Ewing, J Alder, Z Ma

Affiliation

¹ Infectious Disease Research, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064-3537, USA.

PMID: 10737737
DOI: 10.1021/jm990618n

No abstract available

MeSH terms

Animals
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Drug Design
Drug Resistance, Microbial
Haemophilus influenzae / drug effects*
Lung / microbiology
Lung Diseases / drug therapy
Macrolides / chemical synthesis*
Macrolides / chemistry
Macrolides / pharmacology
Mice
Models, Molecular
Rats
Respiratory Tract Infections / microbiology
Staphylococcal Infections / drug therapy
Staphylococcus / drug effects*
Streptococcal Infections / drug therapy
Streptococcus / drug effects*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Macrolides