A statistically robust variance-components approach for quantitative trait linkage analysis

Ann Hum Genet. 1999 May;63(Pt 3):249-62. doi: 10.1046/j.1469-1809.1999.6330249.x.

Abstract

Previously we showed (Wang, Guerra & Cohen 1998) that a statistically robust version of the Haseman & Elston (1972) sib-pair method greatly increased power to detect linkage in the presence of outliers. In this paper we report on M-estimation to accommodate outliers in the variance-components approach to linkage analysis developed by Amos (1994). Simulations show that in the presence of outliers the robust variance-components approach provides substantially greater power, more precise estimation of heritabilities, and better false-positive rates than the original Gaussian based approach. In the absence of outliers the performance of the robust variance-components approach is similar to that of the Gaussian based approach. For illustration we apply the method to two well characterized lipoprotein systems.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Analysis of Variance
  • Apolipoproteins E / genetics
  • Cholesterol, LDL / genetics
  • Family Health
  • Gene Frequency
  • Genetic Linkage / genetics*
  • Humans
  • Hyperlipoproteinemia Type II / genetics
  • Lipase / genetics
  • Liver / enzymology
  • Models, Genetic
  • Nuclear Family
  • Polymorphism, Genetic
  • Quantitative Trait, Heritable*
  • Statistics as Topic / methods*

Substances

  • Apolipoproteins E
  • Cholesterol, LDL
  • Lipase