RNA on the road to myelin

J Neurocytol. Apr-May 1999;28(4-5):263-70. doi: 10.1023/a:1007097226688.

Abstract

In oligodendrocytes some mRNAs are transported from the perikaryon to the distal processes and localized in the myelin compartment where they are translated. This review describes the cis-acting signals and trans-acting factors that mediate intracellular trafficking of myelin basic protein (MBP) RNA, the prototype for such mRNAs in myelinating glia.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Humans
  • Myelin Sheath / metabolism*
  • Oligodendroglia / metabolism*
  • RNA, Messenger / metabolism*

Substances

  • RNA, Messenger