Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population

Neurosci Lett. 2000 Apr 7;283(2):109-12. doi: 10.1016/s0304-3940(00)00917-4.

Abstract

Several studies have demonstrated that interleukin-6 (IL-6) is involved in the pathogenesis of Alzheimer's disease (AD). We previously reported on an association between the C allele of a variable number of tandem repeat polymorphism in the 3' flanking region of IL-6 gene (IL-6vntr) and delayed initial onset and reduced AD risk. A novel G/C polymorphism at position -174 in the IL-6 gene promoter (IL-6prom) has recently been identified and appears to influence the regulation of IL-6 expression. We examined this functional polymorphism in 102 AD patients and two control groups of 191 healthy subjects and 160 depressed patients. There was no evidence for an allelic association between IL-6prom polymorphism and earlier age of onset or risk of AD. However, haplotype analysis showed a strong linkage disequilibrium between IL-6vntr and IL-6prom and demonstrated an interaction between IL-6vntr and IL-6prom which modifies AD risk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics*
  • Gene Expression Regulation
  • Gene Frequency
  • Genotype
  • Germany
  • Haplotypes
  • Humans
  • Interleukin-6 / genetics*
  • Minisatellite Repeats
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic*
  • Reference Values
  • Regression Analysis
  • Risk Factors
  • Whites

Substances

  • Interleukin-6