The IKK complex: an integrator of all signals that activate NF-kappaB?

Trends Cell Biol. 2000 Apr;10(4):129-33. doi: 10.1016/s0962-8924(00)01729-3.

Abstract

The NF-kappaB family of transcription factors plays a crucial role in the immune, inflammatory and apoptotic responses. These proteins are normally found in the cytoplasm, retained by interaction with an inhibitory molecule called IkappaB. Activation of the NF-kappaB signalling cascade results in phosphorylation and degradation of IkappaB, allowing nuclear translocation of the NF-kappaB complexes. The recent identification of a high-molecular-weight complex containing two kinases and a regulatory subunit has led to a flurry of new results that shed light on some of the most complex mechanisms contributing to the exquisite regulation of NF-kappaB activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • I-kappa B Kinase
  • NF-kappa B / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*

Substances

  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human