Effects of respiratory and metabolic pH changes and hypoxia on ropivacaine-induced cardiotoxicity in dogs

Br J Anaesth. 2000 Jan;84(1):92-4. doi: 10.1093/oxfordjournals.bja.a013389.


We have studied the effects of acute changes in acid-base status and hypoxia on the cardiotoxic effects of intracoronary injection of ropivacaine in anaesthetized dogs. The effects of intracoronary ropivacaine were compared when ropivacaine was administered during eucapnia and during each of another nine states in random order: hypocapnia, hypercapnia, hypoxia, metabolic alkalosis, metabolic acidosis, combined metabolic acidosis and hypocapnia, combined metabolic alkalosis and hypercapnia, combined hypoxia and hypercapnia, and combined metabolic acidosis and hypoxia. Hypocapnic alkalosis consistently reduced the cardiotoxic effects of intracoronary ropivacaine (P < 0.01). Our findings indicate that induction of hypocapnic alkalosis may provide a useful adjunct to standard resuscitative measure after inadvertent administration of amide local anaesthetic agents.

MeSH terms

  • Acid-Base Imbalance / physiopathology*
  • Amides / adverse effects*
  • Anesthetics, Local / adverse effects*
  • Animals
  • Dogs
  • Electrocardiography / drug effects
  • Hemodynamics / drug effects*
  • Hydrogen-Ion Concentration
  • Hypocapnia / physiopathology
  • Hypoxia / physiopathology*
  • Ropivacaine


  • Amides
  • Anesthetics, Local
  • Ropivacaine