Cell cycle regulation by the Cdc25 phosphatase family

Prog Cell Cycle Res. 2000;4:107-14. doi: 10.1007/978-1-4615-4253-7_10.

Abstract

Activation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes activation during S-phase and plays a role in activating the mitotic kinase Cdk1/cyclin B in the cytoplasm. Active Cdk1/cyclin B then phosphorylates and activates Cdc25C leading to a positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human oncogenes. In addition, Cdc25 is a main player of the G2 arrest caused by DNA damage or in the presence of unreplicated DNA.

Publication types

  • Review

MeSH terms

  • Catalysis
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Cell Division / physiology
  • Fungal Proteins / metabolism*
  • Humans
  • Mitosis / physiology
  • Oncogenes
  • Signal Transduction
  • cdc25 Phosphatases / genetics
  • cdc25 Phosphatases / metabolism*
  • cdc25 Phosphatases / physiology
  • ras-GRF1 / metabolism*

Substances

  • Cell Cycle Proteins
  • Fungal Proteins
  • ras-GRF1
  • CDC25A protein, human
  • CDC25B protein, human
  • cdc25 Phosphatases