Positron emission tomography: radioisotope and radiopharmaceutical production

Australas Phys Eng Sci Med. 1999 Dec;22(4):136-44.


A Centre for Positron Emission Tomography (PET) has been operational within the Department of Nuclear Medicine at the Austin & Repatriation Medical Centre (A&RMC) in Melbourne for seven years. PET is a non-invasive imaging technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic facility consists of a medical cyclotron (10 MeV proton & 5 MeV deuteron), six lead-shielded hotcells with associated radiochemistry facilities, radiopharmacy and a whole body PET scanner. A strong radiolabelling development program, including the production of 15O-oxygen, 15O-carbon monoxide, 15O-carbon dioxide, 15O-water, 13N-ammonia, 18F-FDG, 18F-FMISO, 11C-SCH23390 and 11C-flumazenil has been pursued to support an ambitious clinical and research program in neurology, oncology, cardiology and psychiatry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Drug Design
  • Equipment Design
  • Glucose / metabolism
  • Hypoxia / diagnostic imaging
  • Hypoxia / physiopathology
  • Nervous System Diseases / diagnostic imaging
  • Oxygen / metabolism
  • Quality Control
  • Radioisotopes / chemistry*
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / standards
  • Regional Blood Flow
  • Tomography, Emission-Computed / instrumentation*
  • Tomography, Emission-Computed / methods


  • Radioisotopes
  • Radiopharmaceuticals
  • Glucose
  • Oxygen