Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP)

H C Barlow; K J Bowman; N J Curtin; A H Calvert; B T Golding; B Huang; P J Loughlin; D R Newell; P G Smith; R J Griffin

doi:10.1016/s0960-894x(00)00053-6

Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP)

Bioorg Med Chem Lett. 2000 Mar 20;10(6):585-9. doi: 10.1016/s0960-894x(00)00053-6.

Authors

H C Barlow¹, K J Bowman, N J Curtin, A H Calvert, B T Golding, B Huang, P J Loughlin, D R Newell, P G Smith, R J Griffin

Affiliation

¹ Department of Chemistry, The University, Newcastle upon Tyne, UK.

PMID: 10741559
DOI: 10.1016/s0960-894x(00)00053-6

Abstract

The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to alpha1-acid glycoprotein, is reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Transport, Active / drug effects
Chemical Phenomena
Chemistry, Physical
Drug Resistance, Neoplasm*
Humans
Leukemia L1210 / drug therapy
Nucleosides / metabolism*
Orosomucoid / metabolism*
Pyrimidines / chemical synthesis*
Pyrimidines / pharmacology
Structure-Activity Relationship

Substances

Nucleosides
Orosomucoid
Pyrimidines