Mechanisms of angiogenesis and arteriogenesis

Nat Med. 2000 Apr;6(4):389-95. doi: 10.1038/74651.


Endothelial and smooth muscle cells interact with each other to form new blood vessels. In this review, the cellular and molecular mechanisms underlying the formation of endothelium-lined channels (angiogenesis) and their maturation via recruitment of smooth muscle cells (arteriogenesis) during physiological and pathological conditions are summarized, alongside with possible therapeutic applications.

Publication types

  • Review

MeSH terms

  • Animals
  • Arterioles / physiopathology*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / growth & development
  • Humans
  • Muscle, Smooth, Vascular / physiopathology
  • Neovascularization, Pathologic* / metabolism
  • Neovascularization, Pathologic* / physiopathology
  • Neovascularization, Physiologic / physiology