Metal ions in ribozyme folding and catalysis

Curr Opin Chem Biol. 2000 Apr;4(2):166-70. doi: 10.1016/s1367-5931(99)00071-x.


Current research is reshaping basic theories regarding the roles of metal ions in ribozyme function. No longer viewed as strict metalloenzymes, some ribozymes can access alternative catalytic mechanisms depending on the identity and availability of metal ions. Similarly, reaction conditions can allow different folding pathways to predominate, with divalent cations sometimes playing opposing roles.

Publication types

  • Review

MeSH terms

  • Animals
  • Catalysis
  • Cations
  • Metalloproteins / chemistry
  • Metalloproteins / metabolism
  • Metals*
  • Models, Molecular
  • Nucleic Acid Conformation*
  • RNA, Catalytic / chemistry*
  • RNA, Catalytic / metabolism*


  • Cations
  • Metalloproteins
  • Metals
  • RNA, Catalytic