Evidence of endothelium involvement in the pathophysiology of hydrops fetalis?

Early Hum Dev. 2000 Mar;57(3):205-9. doi: 10.1016/s0378-3782(99)00063-8.

Abstract

A fetus with signs of hydrops is at high risk of intrauterine death. The pathophysiology of hydrops fetalis is still unclear. We found decreased concentrations of cyclic guanosine monophosphate in fetal plasma of alloimmunized pregnancies complicated by hydrops fetalis, which might suggest reduced nitric oxide production due to injury of fetal vascular endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Creatinine / blood
  • Cyclic GMP / blood
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / physiopathology*
  • Female
  • Fetal Blood / chemistry
  • Fetus / physiopathology*
  • Fibronectins / blood
  • Hematocrit
  • Hemoglobins / analysis
  • Humans
  • Hydrops Fetalis / etiology*
  • Hydrops Fetalis / mortality
  • Hydrops Fetalis / physiopathology
  • Immunoenzyme Techniques
  • Platelet Count
  • Pregnancy
  • Pregnancy Complications / etiology*
  • Pregnancy Complications / physiopathology
  • Serum Albumin / analysis

Substances

  • Fibronectins
  • Hemoglobins
  • Serum Albumin
  • Creatinine
  • Cyclic GMP