[Combination of antimalarial drugs mepacrine and chloroquine in therapy refractory cutaneous lupus erythematosus]

Hautarzt. 2000 Feb;51(2):82-5. doi: 10.1007/s001050050017.
[Article in German]


Antimalarials represent the first line in treatment of cutaneous lupus erythematosus (LE). However, some patients show no improvement on monotherapy with chloroquine or hydroxychloroquine. A 30-year-old female patient had treatment-resistant cutaneous LE exhibiting features of both LE tumidus and subacute cutaneous LE. Previously, the patient had been unsuccessfully treated with chloroquine, hydroxychloroquine, dapsone, and azathioprine, each in combination with variable doses of prednisolone. However, the LE lesions increased during these therapeutic regimens. A combination of chloroquine and mepacrine therapy led to improvement and then total clearing after 4 months of treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antimalarials / administration & dosage*
  • Antimalarials / adverse effects
  • Chloroquine / administration & dosage*
  • Chloroquine / adverse effects
  • Drug Therapy, Combination
  • Facial Dermatoses / diagnosis
  • Facial Dermatoses / drug therapy
  • Female
  • Humans
  • Lupus Erythematosus, Discoid / diagnosis
  • Lupus Erythematosus, Discoid / drug therapy*
  • Quinacrine / administration & dosage*
  • Quinacrine / adverse effects


  • Antimalarials
  • Chloroquine
  • Quinacrine