Plasmodium falciparum clones resistant to (S)-9-(3-hydroxy-2-phosphonylmethoxy-propyl)adenine carry amino acid substitutions in DNA polymerase delta

Mol Biochem Parasitol. 2000 Feb 25;106(1):175-80. doi: 10.1016/s0166-6851(99)00202-9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Amino Acid Sequence
  • Amino Acid Substitution / genetics
  • Animals
  • Antiparasitic Agents / pharmacology*
  • Binding Sites
  • DNA-Directed DNA Polymerase / chemistry
  • DNA-Directed DNA Polymerase / genetics*
  • Drug Resistance / genetics
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Organophosphonates*
  • Organophosphorus Compounds / pharmacology*
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics
  • Plasmodium falciparum / radiation effects
  • Sequence Alignment
  • Ultraviolet Rays

Substances

  • Antiparasitic Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
  • DNA-Directed DNA Polymerase
  • Adenine