Combined use of an amniotic membrane and tissue adhesive in treating corneal perforation: a case report

Ophthalmic Surg Lasers. Mar-Apr 2000;31(2):151-4.


We report a new method combining the use of an amniotic membrane and cyanocrylate tissue adhesive to seal a corneal perforation. A 47-year-old male suffered from an alkali injury complicated with corneal melting and perforation in the left eye. We placed an amniotic membrane of optimal size in the anterior chamber directly under the corneal perforation lesion. The cyanocrylate tissue adhesive was then applied over the perforation site and sealed successfully. Three weeks later, the tissue adhesive had dislodged. The amniotic membrane had sealed the perforated lesion and was well adhered to the surrounding corneal tissue with complete epithelial covering. Vision was 20/25 six months after the operation. The combined use of an amniotic membrane and tissue adhesive is a promising method in the treatment of corneal perforation.

Publication types

  • Case Reports

MeSH terms

  • Amnion / transplantation*
  • Burns, Chemical / pathology
  • Burns, Chemical / therapy*
  • Combined Modality Therapy
  • Cornea / pathology
  • Cornea / surgery*
  • Corneal Injuries
  • Cyanoacrylates / therapeutic use*
  • Eye Burns / chemically induced*
  • Eye Burns / pathology
  • Eye Burns / therapy
  • Humans
  • Male
  • Middle Aged
  • Rupture
  • Sodium Hydroxide / adverse effects*
  • Wound Healing


  • Cyanoacrylates
  • Sodium Hydroxide