Abstract
Chemical resolution of racemic 18-methoxycoronaridine (18-MC) was achieved by the formation of its diastereomeric sulfonamides with either (R)-(-)- or (S)-(+)-camphorsulfonyl chloride. Preliminary assessment of (+)-, (-)-, and (+/-)-18-MC x HCl showed similar effects on morphine self-administration in a rat model, and similar affinities at the kappa opioid receptors.
MeSH terms
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Animals
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Ibogaine / analogs & derivatives*
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Ibogaine / chemical synthesis
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Ibogaine / pharmacology
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Morphine / pharmacology
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Morphine Dependence / drug therapy*
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Narcotics / pharmacology
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Rats
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Receptors, Opioid, delta / drug effects
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Receptors, Opioid, kappa / drug effects
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Receptors, Opioid, mu / drug effects
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Self Administration
Substances
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Narcotics
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Ibogaine
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Morphine
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18-methoxycoronaridine