Haemostatic factors in human peripheral afferent lymph

Thromb Haemost. 2000 Mar;83(3):427-32.


Peripheral afferent lymph was obtained by cannulation of a collecting vessel in 17 healthy men (mean age 26 years). Lymph/plasma ratios of all vitamin K-dependent factors were lower than expected from molecular weight. Factor VII, factor IX and tissue factor pathway inhibitor (TFPI) lymph/plasma activity ratios were higher than antigen ratios. Activated factor VII (FVIIa) and TFPI-Xa complex concentrations were higher in lymph than plasma, and the raised FVIIa did not appear to be due to cannulation. The fibrinogen lymph/plasma activity (Clauss) ratio averaged about 20% of the antigen ratio. The result of an ELISA for D-dimer was higher in lymph than plasma, often more than five-fold. This high level in lymph was not explored but may indicate proteolysis of fibrinogen and fibrin with release of D-like and D-dimer-like fragments in interstitial fluid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Factor IX / metabolism
  • Factor VII / metabolism
  • Factor VIIa / metabolism
  • Factor Xa / metabolism
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Fibrinogen / metabolism
  • Fibrinolytic Agents / blood
  • Hemostasis / physiology*
  • Humans
  • Lipoproteins / blood
  • Lipoproteins / metabolism
  • Lymph / physiology*
  • Male


  • Fibrin Fibrinogen Degradation Products
  • Fibrinolytic Agents
  • Lipoproteins
  • fibrin fragment D
  • lipoprotein-associated coagulation inhibitor
  • Factor VII
  • Factor IX
  • Fibrinogen
  • Factor VIIa
  • Factor Xa