Excitation-contraction coupling in skeletal muscle: comparisons with cardiac muscle

Clin Exp Pharmacol Physiol. 2000 Mar;27(3):216-24. doi: 10.1046/j.1440-1681.2000.03224.x.


1. The present review describes the mechanisms involved in controlling Ca2+ release from the sarcoplasmic reticulum (SR) of skeletal muscle, which ultimately regulates contraction. 2. Comparisons are made between cardiac and skeletal muscle with respect to: (i) the role of the dihydropyridine receptors (DHPR) as Ca2+ channels and voltage-sensors; (ii) the regulation of the ryanodine receptor (RyR)/Ca2+-release channels in the SR; and (iii) the importance of Ca2+-induced Ca2+ release. 3. It is shown that the key differences of the skeletal muscle Ca2+-release channel (RyR1), namely the increase in its stimulation by ATP and its inhibition by Mg2+, are critical for its direct regulation by the associated DHPR and, consequently, for the fast, accurate control of skeletal muscle contraction.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Heart / physiology*
  • Humans
  • Muscle Contraction / physiology*
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • Myocardial Contraction / physiology*


  • Calcium