RNA Polymerase Structure-Function: Insights Into Points of Transcriptional Regulation

Curr Opin Microbiol. 2000 Apr;3(2):118-25. doi: 10.1016/s1369-5274(00)00062-x.

Abstract

The crystal structure of Thermus aquaticus RNA polymerase (RNAP) with 3.3 A resolution has recently been described. The high degree of sequence similarity between T. aquaticus RNAP and the prototypical RNAP from Escherichia coli invites comparison of the new structural data with genetic and biochemical results that defined the interaction sites of E. coli RNAP with transcription regulators.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • DNA-Directed RNA Polymerases / chemistry*
  • DNA-Directed RNA Polymerases / metabolism*
  • Escherichia coli / enzymology*
  • Gene Expression Regulation, Bacterial*
  • Models, Molecular
  • Thermus / enzymology*
  • Transcription Factors / metabolism
  • Transcription, Genetic / genetics*

Substances

  • Transcription Factors
  • DNA-Directed RNA Polymerases