Two-component and phosphorelay signal transduction

Curr Opin Microbiol. 2000 Apr;3(2):165-70. doi: 10.1016/s1369-5274(00)00070-9.


Two-component and phosphorelay signal transduction systems are the major means by which bacteria recognize and respond to a variety of environmental stimuli. Recent results have implicated these systems in the regulation of a variety of essential processes including cell-cycle progression, pathogenicity, and developmental pathways. Elucidation of the structures of the interacting domains is leading to an understanding of the mechanisms of molecular recognition and phosphotransfer in these systems.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacteria / enzymology
  • Bacteria / growth & development
  • Bacteria / metabolism*
  • Bacteria / pathogenicity
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism*
  • Genes, Regulator / physiology
  • Phosphorylation
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism
  • Protein Structure, Tertiary
  • Signal Transduction*
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism


  • Bacterial Proteins
  • Transcription Factors
  • Protein Kinases