Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo

Neurology. 2000 Mar 28;54(6):1382-5. doi: 10.1212/wnl.54.6.1382.


The authors performed a double-blind, double-dummy study to compare the efficacy of verapamil with placebo in the prophylaxis of episodic cluster headache. After 5 days' run-in, 15 patients received verapamil (120 mg tid) and 15 received placebo (tid) for 14 days. The authors found a significant reduction in attack frequency and abortive agents consumption in the verapamil group. Side effects were mild. These findings provide objective evidence for the effectiveness of verapamil in episodic cluster headache prophylaxis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cluster Headache / drug therapy*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Verapamil / adverse effects
  • Verapamil / therapeutic use*


  • Verapamil