Risk factors for lacunar stroke: a case-control transesophageal echocardiographic study

Neurology. 2000 Mar 28;54(6):1385-7. doi: 10.1212/wnl.54.6.1385.


To reassess the independent risk factors for lacunar stroke and to clarify the role of potential embolic sources, we conducted a case-control study using transesophageal echocardiography and duplex ultrasonography. Among 62 consecutive patients with their first lacunar stroke and 202 normal controls, we found that hypertension (p < 0.001), smoking (p = 0.001), and aortic arch atheroma (p = 0.006) were independently associated with an increased risk of lacunar stroke. Whether proximal aortic arch atheroma is mechanistically associated with lacunar stroke or merely coexistent is uncertain.

MeSH terms

  • Aged
  • Case-Control Studies
  • Echocardiography, Transesophageal*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Stroke / diagnostic imaging*
  • Tomography, X-Ray Computed