The risk of premalignant and malignant pathology in endometrial polyps

Acta Obstet Gynecol Scand. 2000 Apr;79(4):317-20.


Objective: To evaluate the risk of premalignant and malignant pathology among endometrial polyps.

Design: Prospective cohort study.

Setting: Minimal Access Surgical Training (MAST) center in a large teaching hospital.

Methods: Among 248 patients seen in outpatient hysteroscopy clinic (1996-97), 62 had endometrial polyps. All patients had endometrial sampling for histological assessment. To determine the magnitude of malignant potential among polyps, we compared the pathological findings in polyps (cases) with non-polypoidal specimens (controls).

Results: Out of 62 polyps, histologically 53 (85.5%) were benign, seven (11.3%) had hyperplasia, and two (3.2%) were associated with malignancy. Hyperplasia was more frequent in endometrial specimens with polyps than in those without (11.3% vs 4.3%, p=0.04), but the incidence of carcinoma in the two groups was the same (3.2% vs 3.2%, p= 1.0).

Conclusion: In abnormal uterine bleeding, hyperplasia was, but cancer was not, more common in women with endometrial polyps compared to those without polyps.

MeSH terms

  • Cohort Studies
  • Endometrial Hyperplasia / etiology
  • Endometrial Hyperplasia / pathology
  • Endometrial Neoplasms / etiology
  • Endometrial Neoplasms / pathology*
  • Female
  • Humans
  • Hysterectomy
  • Middle Aged
  • Polyps / complications
  • Polyps / pathology*
  • Precancerous Conditions / pathology*
  • Prospective Studies
  • Risk Assessment
  • Uterine Diseases / pathology*
  • Uterine Hemorrhage / etiology
  • Uterine Hemorrhage / pathology