Long-term persistence of a discotheque-associated invasive Neisseria meningitidis group C strain as proven by pulsed-field gel electrophoresis and porA gene sequencing

J Clin Microbiol. 2000 Apr;38(4):1638-40. doi: 10.1128/JCM.38.4.1638-1640.2000.

Abstract

A cluster of a Neisseria meningitidis serogroup C strain causing invasive disease was investigated. Five out of seven cases were associated with a particular discotheque. The strains were indistinguishable, as revealed by pulsed-field gel electrophoresis and sequencing of variable regions of the porA gene, but caused strikingly different clinical presentations during 5 months.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Dancing*
  • Disease Outbreaks*
  • Electrophoresis, Gel, Pulsed-Field*
  • Female
  • Humans
  • Infant
  • Male
  • Meningococcal Infections / epidemiology*
  • Meningococcal Infections / microbiology
  • Middle Aged
  • Neisseria meningitidis / classification
  • Neisseria meningitidis / genetics
  • Neisseria meningitidis / pathogenicity*
  • Porins / genetics*
  • Sweden / epidemiology

Substances

  • Porins
  • porin protein, Neisseria