A bayesian analysis for spatial processes with application to disease mapping

Stat Med. 2000 Apr 15;19(7):957-74. doi: 10.1002/(sici)1097-0258(20000415)19:7<957::aid-sim396>3.0.co;2-q.

Abstract

In epidemiology, maps of disease rates and disease risk provide a spatial perspective for researching disease aetiology. For rare diseases or when the population base is small, the rate and risk estimates may be unstable. We propose using a Bayesian analysis based on the conditional autoregressive (CAR) process that will spatially smooth disease rates or risk estimates by allowing each site to 'borrow strength' from its neighbours. Covariates may be included in the model in such a way as to establish a possible association between risk factors and disease incidence. Bayesian inferences are implemented from a direct resampling scheme where large samples are generated from the various posterior distributions. The methodology is demonstrated with a simulation that assesses the effect of sample size and the model parameters on inferences for the parameters. Our approach is also used to spatially smooth district lip cancer rates in Scotland using the CAR model with a covariate that allows for exposure to sunlight.

MeSH terms

  • Bayes Theorem*
  • Epidemiologic Methods*
  • Humans
  • Incidence
  • Lip Neoplasms / epidemiology
  • Lip Neoplasms / etiology
  • Risk Factors
  • Scotland / epidemiology
  • Sunlight / adverse effects