Weight loss and plasma lipids

Curr Opin Lipidol. 2000 Feb;11(1):65-70. doi: 10.1097/00041433-200002000-00010.


Although weight loss is associated with improvements in the plasma lipid profile, factors other than weight loss per se are involved. Energy restriction resulting in even modest weight loss suppresses endogenous cholesterol synthesis, which contributes to observed decline in circulating lipid concentrations. Whether individuals have stabilized weight or are still actively losing weight affects the magnitude of LDL cholesterol reduction as well as the direction of HDL cholesterol change. Hence, it is important to consider the timing of lipid measurements in the interpretation of the plasma lipid response to weight loss. Another important factor is the dietary composition of the weight loss strategy, with evidence that dietary fatty acid profile and amount can differentially influence the lipid response similar to that observed in energy balance studies. Other issues such as gender, and exercise during weight loss are also relevant. However, whether the lipid changes that are observed in the short term are sustained in the long term and whether the manner of weight loss has any impact on long-term outcomes remains to be determined.

Publication types

  • Review

MeSH terms

  • Dietary Carbohydrates / administration & dosage
  • Dietary Fats / administration & dosage
  • Exercise / physiology
  • Humans
  • Hyperlipidemias
  • Lipids / blood*
  • Obesity / blood
  • Obesity / therapy
  • Sex Characteristics
  • Weight Loss*


  • Dietary Carbohydrates
  • Dietary Fats
  • Lipids