Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women

Lancet. 2000 Mar 11;355(9207):898-9. doi: 10.1016/s0140-6736(99)05463-x.

Abstract

The link between serum insulin-like growth factor 1 (IGF-1) and postmenopausal osteoporosis remains controversial. In this study of healthy postmenopausal women, decreased serum concentrations of IGF-1 were strongly associated with an increased risk of osteoporotic fractures independently of bone-mineral density.

Publication types

  • Letter

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bone Density / physiology
  • Female
  • Fractures, Spontaneous / blood
  • Fractures, Spontaneous / etiology*
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 / blood
  • Insulin-Like Growth Factor I / deficiency*
  • Middle Aged
  • Osteoporosis, Postmenopausal / blood
  • Osteoporosis, Postmenopausal / etiology*
  • Risk Factors

Substances

  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I