Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities

J Comput Assist Tomogr. Mar-Apr 2000;24(2):259-61. doi: 10.1097/00004728-200003000-00013.


A reticular pattern on high resolution CT (HRCT) invariably represents significant lung pathology and is the dominant feature of irreversible fibrosis. We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis. Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Dyspnea / etiology
  • Female
  • Humans
  • Lung Diseases, Interstitial / chemically induced*
  • Lung Diseases, Interstitial / diagnostic imaging*
  • Male
  • Nitrofurantoin / adverse effects*
  • Pulmonary Fibrosis / chemically induced
  • Pulmonary Fibrosis / diagnostic imaging
  • Remission, Spontaneous
  • Tomography, X-Ray Computed*
  • Urinary Tract Infections / drug therapy


  • Nitrofurantoin