The HP1 protein family: getting a grip on chromatin

Curr Opin Genet Dev. 2000 Apr;10(2):204-10. doi: 10.1016/s0959-437x(00)00058-7.


HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-dependent effects on heterochromatin-induced gene silencing. Recently, membership of the HP1 protein family has expanded tremendously. A number of intriguing interactions between HP1 and other proteins have been described, implicating HP1 in gene regulation, DNA replication, and nuclear architecture.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / genetics*
  • Chromatin / metabolism*
  • Chromosomal Proteins, Non-Histone / genetics*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Humans
  • Multigene Family
  • Protein Binding / genetics


  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • heterochromatin-specific nonhistone chromosomal protein HP-1