mRNA stability in eukaryotes

Curr Opin Genet Dev. 2000 Apr;10(2):193-8. doi: 10.1016/s0959-437x(00)00063-0.


During the past two years, the role of the proteins HuR and hnRNP D in regulated mRNA degradation in humans has become clearer, and a putative mRNA deadenylase, DAN or PARN, has been identified. In yeast, the relationship between translation and mRNA turnover is clearer, but the mRNA decapping process has turned out to be unexpectedly complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / metabolism*
  • Humans
  • RNA Stability*
  • RNA, Messenger / metabolism*


  • RNA, Messenger