Promoter targeting and chromatin remodeling by the SWI/SNF complex

Curr Opin Genet Dev. 2000 Apr;10(2):187-92. doi: 10.1016/s0959-437x(00)00068-x.

Abstract

The SWI/SNF complex is a 2 MDa multi-subunit DNA-dependent ATPase that contributes to the regulation of gene transcription by altering chromatin structure. Recent studies have revealed that the SWI/SNF complex is targeted to promoters via direct interactions with transcription activators and have provided insights into mechanisms by which the complex alters nucleosome structure and contributes to the remodeling of chromatin.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • Adenosine Triphosphatases / metabolism
  • Animals
  • Chromatin / enzymology*
  • Chromatin / genetics*
  • Chromatin / metabolism
  • DNA Helicases
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Humans
  • Macromolecular Substances
  • Nuclear Proteins*
  • Promoter Regions, Genetic / genetics*
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Nuclear Proteins
  • RSC complex, S cerevisiae
  • SMARCA1 protein, human
  • SMARCA2 protein, human
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Adenosine Triphosphatases
  • SMARCA4 protein, human
  • DNA Helicases