The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice

K Yamanaka; K Katsumata; K Ikuma; A Hasegawa; M Nakano; S Okada

doi:10.1016/s0304-3835(99)00440-1

The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice

Cancer Lett. 2000 Apr 28;152(1):79-85. doi: 10.1016/s0304-3835(99)00440-1.

Authors

K Yamanaka¹, K Katsumata, K Ikuma, A Hasegawa, M Nakano, S Okada

Affiliation

¹ Nihon University College of Pharmacy, 7-7-1 Narashinodai, Funabashi, Chiba, Japan. yamanaka@pha.nihon-u.ac.jp

PMID: 10754209
DOI: 10.1016/s0304-3835(99)00440-1

Abstract

The effect of dimethylarsinic acid (DMA) on skin tumorigenesis by UVB irradiation was examined. Hairless mice (Hos: HR-1) irradiated with UVB at a dose of 2 kJ/m(2) twice weekly, were fed with drinking water containing 1000 ppm DMA, a main metabolite of inorganic arsenics, produced more skin tumors than DMA-untreated mice. Histopathological examination revealed that the mouse malignant tumors with severe atypism appeared only in the treatment group of UVB plus 1000 ppm DMA. These positive results point out the importance of dimethylated metabolites of inorganic arsenic in the process of skin carcinogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Animals
Cacodylic Acid / pharmacology*
Disease Progression
Female
Mice
Mice, Hairless
Neoplasms, Radiation-Induced*
Skin Neoplasms / etiology*
Skin Neoplasms / pathology
Time Factors
Ultraviolet Rays / adverse effects*

Substances

Cacodylic Acid