Abstract
Forty-two enucleated eyes of 42 patients with unilateral retinoblastoma were studied histologically, including histochemically examination with anti-nm23 polyclonal antibody which does not recognise cDNA but its product. Primary tumours of >15 mm diameter with less evidence of apoptosis and with the most pleomorphic and anaplastic nuclei were associated with an increased risk of distant metastasis, but rosette formation did not discriminate. A high intensity of nm23 staining also indicated a tendency to metastasize, consistent with childhood neuroblastoma but in contrast to findings in carcinoma of the breast, colon and uterine cervix.
Copyright 2000 S. Karger AG, Basel
MeSH terms
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Antigens, Neoplasm / biosynthesis*
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Biomarkers, Tumor / biosynthesis
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Cell Survival
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Child
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Child, Preschool
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Disease Progression
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Female
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Humans
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Immunoenzyme Techniques
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Infant
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Male
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Monomeric GTP-Binding Proteins / biosynthesis*
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NM23 Nucleoside Diphosphate Kinases
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Neoplasm Metastasis
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Nucleoside-Diphosphate Kinase / biosynthesis*
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Retinal Neoplasms / enzymology*
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Retinal Neoplasms / pathology
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Retinal Neoplasms / surgery
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Retinoblastoma / enzymology*
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Retinoblastoma / pathology
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Retinoblastoma / secondary
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Retinoblastoma / surgery
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Retrospective Studies
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Transcription Factors / biosynthesis*
Substances
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Antigens, Neoplasm
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Biomarkers, Tumor
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NM23 Nucleoside Diphosphate Kinases
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Transcription Factors
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NME1 protein, human
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Nucleoside-Diphosphate Kinase
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Monomeric GTP-Binding Proteins