Virucidal and chlamydicidal activities of eye drops with povidone-iodine liposome complex

Ophthalmic Res. Mar-Jun 2000;32(2-3):118-25. doi: 10.1159/000055600.

Abstract

Povidone-iodine (PVP-I) is a broad-spectrum microbicide with in vitro activity against bacteria, viruses, fungi and protozoans. A 5% solution of PVP-I proved to be highly effective in ophthalmic surgery for the prophylaxis of endophthalmitis. For the antiseptic treatment of eye infections a novel application form of PVP-I has been developed by using a PVP-I liposome complex which demonstrated an excellent antimicrobial efficacy. In this study it could be shown that the novel liposomal formulations containing 2.5 or 5% PVP-I were as active as the aqueous solution against herpes simplex virus type 1, adenovirus type 8, coxsackievirus A9 and Chlamydia trachomatis in cell culture referring to equal PVP-I concentrations. Long-term cytotoxicity experiments demonstrated a moderate cytotoxicity for both formulations with a better tolerability of the liposomal PVP-I formulation compared with the aqueous solution. There is no evidence for a genotoxic activity of these agents.

Publication types

  • Comparative Study

MeSH terms

  • Adenoviruses, Human / drug effects*
  • Animals
  • Anti-Infective Agents, Local / pharmacology*
  • Chlamydia trachomatis / drug effects*
  • Chlorocebus aethiops
  • Dose-Response Relationship, Drug
  • Enterovirus / drug effects*
  • Herpesvirus 1, Human / drug effects*
  • Humans
  • Liposomes
  • Male
  • Ophthalmic Solutions / pharmacology*
  • Povidone-Iodine / pharmacology*
  • Rabbits
  • Vero Cells

Substances

  • Anti-Infective Agents, Local
  • Liposomes
  • Ophthalmic Solutions
  • Povidone-Iodine