The suckling mouse model of cholera

Trends Microbiol. 2000 Apr;8(4):189-91. doi: 10.1016/s0966-842x(00)01721-2.

Abstract

Vibrio cholerae colonization of the suckling mouse intestine is a commonly used animal model for the human diarrheal disease cholera. This model has a number of advantages as well as disadvantages, and has been extremely useful in the identification and characterization of proven and putative virulence factors involved in human cholera.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Newborn
  • Animals, Suckling
  • Cholera* / microbiology
  • Cholera* / mortality
  • Cholera* / pathology
  • Disease Models, Animal*
  • Disease Susceptibility
  • Humans
  • Intestines / microbiology
  • Intestines / pathology
  • Mice*
  • Vibrio cholerae / genetics
  • Vibrio cholerae / pathogenicity*
  • Vibrio cholerae / physiology*
  • Virulence