Abstract
[formula: see text] (-)-Gymnodimine is a member of a unique class of potent marine toxins possessing imines within a spirocylic array. Herein we report the synthesis of the tetrahydrofuran fragment and a strategy toward the spirocyclic imine fragment of this family of toxins. Key reactions include an asymmetric anti-aldol reaction to set the stereochemistry of the tetrahydrofuran and a formal, intermolecular Diels-Alder reaction involving an alpha-methylene-delta-lactam and a dienyne.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Furans
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Heterocyclic Compounds, 3-Ring / chemical synthesis*
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Heterocyclic Compounds, 3-Ring / chemistry*
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Hydrocarbons, Cyclic*
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Imines*
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Indicators and Reagents
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Marine Toxins / chemical synthesis*
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Marine Toxins / chemistry*
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Stereoisomerism
Substances
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Furans
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Heterocyclic Compounds, 3-Ring
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Hydrocarbons, Cyclic
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Imines
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Indicators and Reagents
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Marine Toxins
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gymnodimine