Abstract
The phototherapeutic properties and tissue distribution of hypericin were investigated in DBA/2 mice bearing subcutaneously transplanted P388 lymphoma cells. The efficacy of the photodynamic therapy (PDT) 2 h after administration of hypericin (2, 5, or 20 mg/kg, i.p., 120 J/cm2, 595 nm) was substantially greater than the efficacy after a 24 h interval. PDT with Photofrin (5 mg/kg, i.p., 24-h interval, 120 J/cm2, 630 nm) showed no significant antitumoral effect. The hypericin uptake in some tissues was measured after administration of hypericin (5 or 20 mg/kg, i.p.) up to 168 h. A comparison of the distribution data and the PDT efficacy at various intervals suggests that the plasma concentration of hypericin, and to a lesser extent the tumor uptake, determines the tumor response to PDT with hypericin.
MeSH terms
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Animals
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Anthracenes
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / therapeutic use*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Female
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Injections, Intraperitoneal
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Kidney / metabolism
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Liver / metabolism
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Mice
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Mice, Inbred DBA
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Muscles / metabolism
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Neoplasms, Experimental / drug therapy*
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Neoplasms, Experimental / metabolism
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Neoplasms, Experimental / surgery
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Perylene / analogs & derivatives*
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Perylene / blood
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Perylene / pharmacokinetics
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Perylene / therapeutic use
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Photochemotherapy*
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Radiation-Sensitizing Agents / pharmacokinetics
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Radiation-Sensitizing Agents / therapeutic use*
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Skin / metabolism
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Spleen / metabolism
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Survival Analysis
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Time Factors
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Tissue Distribution
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Treatment Outcome
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Tumor Cells, Cultured
Substances
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Anthracenes
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Antineoplastic Agents
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Radiation-Sensitizing Agents
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Perylene
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hypericin