Proteolysis in MHC class II antigen presentation: who's in charge?

Immunity. 2000 Mar;12(3):233-9. doi: 10.1016/s1074-7613(00)80176-4.


Antigen-presenting cells (APC) degrade proteins intracellularly to generate peptides, which are then bound by products of the major histocompatibility complex (MHC) and exposed on the surface of the APC for recognition by T cells. The supply of antigenic peptides and their association with MHC molecules requires the concerted action of a cohort of accessory molecules that includes chaperones, transporters of peptides, and the proteases that degrade the antigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Antigen Presentation*
  • Cathepsins / genetics
  • Cathepsins / physiology*
  • Cell Compartmentation
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Polymorphism, Genetic


  • Histocompatibility Antigens Class II
  • Cathepsins