Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex

Neuroreport. 2000 Mar 20;11(4):893-7. doi: 10.1097/00001756-200003200-00046.


When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p <0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p <0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.

Publication types

  • Corrected and Republished Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Eating / physiology
  • Humans
  • Magnetic Resonance Imaging
  • Observer Variation
  • Olfactory Pathways / anatomy & histology*
  • Olfactory Pathways / physiology*
  • Prefrontal Cortex / anatomy & histology*
  • Prefrontal Cortex / physiology*
  • Receptors, Odorant / physiology
  • Reward
  • Satiation / physiology*
  • Smell / physiology*


  • Receptors, Odorant