Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy

Int J Radiat Oncol Biol Phys. 2000 Apr 1;47(1):13-47. doi: 10.1016/s0360-3016(99)00559-3.


In 1997, the National Cancer Institute (NCI) led an effort to revise and expand the Common Toxicity Criteria (CTC) with the goal of integrating systemic agent, radiation, and surgical criteria into a comprehensive and standardized system. Representatives from the Radiation Therapy Oncology Group (RTOG) participated in this process in an effort to improve acute radiation related criteria and to achieve better clarity and consistency among modalities. CTC v. 2.0 replaces the previous NCI CTC and the RTOG Acute Radiation Morbidity Scoring Criteria and includes more than 260 individual adverse events with more than 100 of these applicable to acute radiation effects. One of the advantages of the revised criteria for radiation oncology is the opportunity to grade acute radiation effects not adequately captured under the previous RTOG system. A pilot study conducted by the RTOG indicated the new criteria are indeed more comprehensive and were preferred by research associates. CTC v. 2.0 represents an improvement in the evaluation and grading of acute toxicity for all modalities.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Digestive System / drug effects
  • Digestive System / radiation effects
  • Humans
  • Medical Records
  • Mucous Membrane / drug effects
  • Mucous Membrane / radiation effects
  • Neoplasms / drug therapy
  • Neoplasms / radiotherapy
  • Neoplasms / therapy*
  • Pilot Projects
  • Radiation Injuries / classification*
  • Radiodermatitis / classification
  • Reference Standards
  • Severity of Illness Index*
  • Stomatitis / classification


  • Antineoplastic Agents