CR3: a general purpose adhesion-recognition receptor essential for innate immunity

Microbes Infect. 2000 Mar;2(3):289-94. doi: 10.1016/s1286-4579(00)00299-9.


CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity*
  • Integrins / genetics
  • Integrins / immunology*
  • Ligands
  • Macrophage-1 Antigen / genetics
  • Macrophage-1 Antigen / immunology*
  • Mice
  • Mice, Knockout
  • Phagocytosis
  • Signal Transduction / immunology


  • Integrins
  • Ligands
  • Macrophage-1 Antigen