[A chronic hyperimmunocomplex process and its interrelationship with free radical-generating systems]

Fiziol Zh. 2000;46(1):17-24.
[Article in Ukrainian]


On chronic hyperimmunocomplex process (CHIP) model in rats of Wistar line (Cochrane C., Koffen D., 1973) we determined cAMP and cGMP concentration, nitrogen oxide (NO), urine, urine acid,--in muscle and clearance organs, and also in plasma. In result of carried out investigations there was determined the increase of large and middle CIC in blood plasma, their fixation on endothelium of aorta bifurcation and glomerula basal membrane, partially on liver cells. There was revealed considerable disbalance of cyclic nucleotides concentration in kidneys homogenates, spleen and plasma, with guanils fall (adenil index, what is interconnected with NO level lowering in all cases and urine increase in plasma, simultaneously with its decrease in number--in kidneys and spleen. Urinic acid increased in number in kidneys, spleen, plasma. These changes create favourable background for damaging of endothelium-neutrophil-thrombocyte cooperation through hemokinin, moleculo-adhesive, fermentative mechanism with further development of proliferative-remodulating processes in vessel wall.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antigen-Antibody Complex / metabolism
  • Chronic Disease
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism
  • Disease Models, Animal
  • Free Radicals / metabolism
  • Immune Complex Diseases / metabolism*
  • Male
  • Nitric Oxide / metabolism
  • Rats
  • Rats, Wistar
  • Urea / metabolism
  • Uric Acid / metabolism


  • Antigen-Antibody Complex
  • Free Radicals
  • Uric Acid
  • Nitric Oxide
  • Urea
  • Cyclic AMP
  • Cyclic GMP