Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4132-7. doi: 10.1073/pnas.070053397.


Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05. 771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBe Ca6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to RCND with a recombination fraction (theta) of 0.016, supported by a logarithm of odds score of 16.7. C02608 and the adjacent linked markers map to a region of the canine genome corresponding to portions of human chromosomes 1p and 17p. A combination of linkage analysis and direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 and 2 genes (TSC1 and TSC2) and the tumor suppressor gene TP53. These data suggest that RCND may be caused by a previously unidentified tumor suppressor gene and highlight the potential for canine genetics in the study of human disease predisposition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cystadenocarcinoma / genetics
  • Cystadenocarcinoma / veterinary*
  • Dogs
  • Female
  • Genes, p53
  • Genetic Linkage
  • Humans
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / veterinary*
  • Male
  • Pedigree
  • Proteins / genetics
  • Tuberous Sclerosis Complex 1 Protein
  • Tumor Suppressor Proteins


  • Proteins
  • TSC1 protein, human
  • Tuberous Sclerosis Complex 1 Protein
  • Tumor Suppressor Proteins