Comparative study of D-002 versus sulfasalazine on acetic acid-induced colitis in rats

Drugs Exp Clin Res. 2000;26(1):13-7.

Abstract

D-002 is a natural mixture of higher aliphatic primary alcohols purified from beeswax and has experimentally proven mild antiinflammatory and effective antiulcer effects. It reduces leukotrienes in the exudate of carrageenan-induced pleurisy and has a protective effect on the preulcerative phase of carrageenan-induced colonic ulceration in the guinea pig. This study was conducted to compare the effect of D-002 and sulfasalazine on acetic acid-induced colitis in rats administered at 1, 5.25 and 100 mg kg-1, 24 h before colitis induction. Significant reductions in wet weight, macroscopic injury, polymorphonuclear infiltration and wall thickness were observed in the colonic mucosa of D-002 and sulfasalazine-treated animals compared with controls, except at the dose of 1 mg kg-1. It was concluded that the effects of D-002 and sulfasalazine were comparable in this experimental model.

Publication types

  • Comparative Study

MeSH terms

  • Acetic Acid
  • Animals
  • Colitis / drug therapy*
  • Colitis / pathology
  • Fatty Alcohols / therapeutic use*
  • Leukotriene B4 / analysis
  • Male
  • Neutrophils / drug effects
  • Neutrophils / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Sulfasalazine / therapeutic use*

Substances

  • D 002
  • Fatty Alcohols
  • Leukotriene B4
  • Sulfasalazine
  • Acetic Acid