Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 100 (6), 635-44

The Stem Cell Population of Arabidopsis Shoot Meristems in Maintained by a Regulatory Loop Between the CLAVATA and WUSCHEL Genes

Affiliations

The Stem Cell Population of Arabidopsis Shoot Meristems in Maintained by a Regulatory Loop Between the CLAVATA and WUSCHEL Genes

H Schoof et al. Cell.

Abstract

The higher-plant shoot meristem is a dynamic structure whose maintenance depends on the coordination of two antagonistic processes, organ initiation and self-renewal of the stem cell population. In Arabidopsis shoot and floral meristems, the WUSCHEL (WUS) gene is required for stem cell identity, whereas the CLAVATA1, 2, and 3 (CLV) genes promote organ initiation. Our analysis of the interactions between these key regulators indicates that (1) the CLV genes repress WUS at the transcript level and that (2) WUS expression is sufficient to induce meristem cell identity and the expression of the stem cell marker CLV3. Our data suggest that the shoot meristem has properties of a self-regulatory system in which WUS/CLV interactions establish a feedback loop between the stem cells and the underlying organizing center.

Similar articles

See all similar articles

Cited by 457 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback