Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma

Int J Mol Med. 2000 May;5(5):505-10. doi: 10.3892/ijmm.5.5.505.


Tenascin-C (TN-C) is one of extracellular matrix glycoproteins. We have immunohistochemically examined the TN-C expression of 33 primary osteosarcoma paraffin-embedded samples. The TN-C expression of the patient group with metastases was higher than that of the group without metastases at significant difference, and the survival curves show a tendency for poor outcome in the high grade staining group. Moreover, the supplemental TN-C had an effect of easier migration of a human osteosarcoma cell line (HOS) in vitro. The results may suggest that TN-C help osteosarcoma cells to migrate and to metastasize.

MeSH terms

  • Adolescent
  • Adult
  • Bone Neoplasms / metabolism*
  • Bone Neoplasms / pathology
  • Bone Neoplasms / secondary*
  • Cell Division
  • Cell Movement
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Osteosarcoma / metabolism*
  • Osteosarcoma / pathology
  • Osteosarcoma / secondary*
  • Predictive Value of Tests
  • Survival Rate
  • Tenascin / metabolism*
  • Tumor Cells, Cultured


  • Tenascin