Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats

Food Chem Toxicol. 2000 May;38(5):443-50. doi: 10.1016/s0278-6915(00)00019-3.

Abstract

Pesticide chemicals may induce oxidative stress leading to generation of free radicals and alterations in antioxidants or oxygen free radical (OFR) scavenging enzymes. Hence, the effect of subchronic malathion (O,O-dimethyl-S-1,2, bis ethoxy carbonyl ethyl phosphorodithioate) exposure was evaluated on lipid peroxidation, glutathione and related enzymes and OFR scavenging enzymes in albino rats. Administration of malathion (20 ppm) for 4 weeks increased the malondialdehyde (MDA) levels in serum, activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes and glutathione reductase (GR) and glutathione S-transferase (GST) in serum. However, it decreased the glutathione (GSH) level in whole blood. Concomitant dietary feeding of Zingiber officinales Rosc (ginger 1%, w/w) significantly attenuated malathion induced lipid peroxidation and oxidative stress in these rats. These results indicate the possible involvement of free radicals in organophosphate-induced toxicity and highlight the protective action of ginger, an indigenous medicinal plant product.

MeSH terms

  • Animals
  • Diet
  • Free Radicals / blood
  • Ginger*
  • Glutathione / metabolism
  • Insecticides / antagonists & inhibitors*
  • Insecticides / toxicity*
  • Lipid Peroxidation / drug effects
  • Malathion / antagonists & inhibitors*
  • Malathion / toxicity*
  • Male
  • Oxidative Stress / drug effects*
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Free Radicals
  • Insecticides
  • Thiobarbituric Acid Reactive Substances
  • Glutathione
  • Malathion