Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats

Food Chem Toxicol. 2000 May;38(5):443-50. doi: 10.1016/s0278-6915(00)00019-3.


Pesticide chemicals may induce oxidative stress leading to generation of free radicals and alterations in antioxidants or oxygen free radical (OFR) scavenging enzymes. Hence, the effect of subchronic malathion (O,O-dimethyl-S-1,2, bis ethoxy carbonyl ethyl phosphorodithioate) exposure was evaluated on lipid peroxidation, glutathione and related enzymes and OFR scavenging enzymes in albino rats. Administration of malathion (20 ppm) for 4 weeks increased the malondialdehyde (MDA) levels in serum, activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes and glutathione reductase (GR) and glutathione S-transferase (GST) in serum. However, it decreased the glutathione (GSH) level in whole blood. Concomitant dietary feeding of Zingiber officinales Rosc (ginger 1%, w/w) significantly attenuated malathion induced lipid peroxidation and oxidative stress in these rats. These results indicate the possible involvement of free radicals in organophosphate-induced toxicity and highlight the protective action of ginger, an indigenous medicinal plant product.

MeSH terms

  • Animals
  • Diet
  • Free Radicals / blood
  • Ginger*
  • Glutathione / metabolism
  • Insecticides / antagonists & inhibitors*
  • Insecticides / toxicity*
  • Lipid Peroxidation / drug effects
  • Malathion / antagonists & inhibitors*
  • Malathion / toxicity*
  • Male
  • Oxidative Stress / drug effects*
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar
  • Thiobarbituric Acid Reactive Substances / metabolism


  • Free Radicals
  • Insecticides
  • Thiobarbituric Acid Reactive Substances
  • Glutathione
  • Malathion